Rats! “Relevant” Chemical Exposures Are Not Relevant

“Close Enough For NIEHS Work,” By Steve Hentges.
The subject of endocrine disruption is not particularly new, with extensive scientific and regulatory attention to endocrine disrupting chemicals (EDCs) over the last 20 years or so. … Quite a few natural and synthetic chemicals exhibit endocrine activity but, in spite of 20 years of research, the field of endocrine disruption continues to be ill-defined and highly controversial.  Two of the current controversies revolve around the related concepts of low-dose effects and non-monotonic dose response curves (NMDRC). In the field of toxicology, a bedrock principle is that “the dose makes the poison,” meaning that a toxicological response is generally expected to increase (or decrease) monotonically with increasing dose.  Read more.