The subject of endocrine disruption is not particularly new, with extensive scientific and regulatory attention to endocrine disrupting chemicals (EDCs) over the last 20 years or so. … Quite a few natural and synthetic chemicals exhibit endocrine activity but, in spite of 20 years of research, the field of endocrine disruption continues to be ill-defined and highly controversial. Two of the current controversies revolve around the related concepts of low-dose effects and non-monotonic dose response curves (NMDRC). In the field of toxicology, a bedrock principle is that “the dose makes the poison,” meaning that a toxicological response is generally expected to increase (or decrease) monotonically with increasing dose. Read more.
Rats! “Relevant” Chemical Exposures Are Not Relevant
