Since the 16th century, the guiding principle of the science of toxicology has been that “the dose makes the poison.” In other words, toxicology tells us what quantity (dose) of a substance will cause harm. This applies to the medicines used by Americans hundreds of millions of times a day to help relieve symptoms or treat illnesses’ for example, the right dose of aspirin or an over-the-counter cold remedy can be a therapeutic godsend, but consuming too much can be lethal. The principle even applies to foods: Large amounts of nutmeg and licorice are notoriously toxic. Read More.